Hydroxylation of salicylate in lungs of Fischer 344 rats: Effects of aging and ozone exposure

被引:13
|
作者
Liu, L [1 ]
Kumarathasan, P [1 ]
Guenette, J [1 ]
Vincent, R [1 ]
机构
[1] HLTH CANADA, HLTH PROTECT BRANCH, ENVIRONM & OCCUPAT TOXICOL DIV, OTTAWA, ON K1A 0L2, CANADA
关键词
hydroxyl radical; oxidative stress; biomarkers;
D O I
10.1152/ajplung.1996.271.6.L995
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The formation of 2,3-dihydroxybenzoic acid (DHBA) from salicylate was measured in the lungs and plasma to assay for the . OH in juvenile (2 mo), adult (9 mo), and senescent (24 mo) Fischer 344 male rats exposed to clean air, 1 part/million (ppm) ozone, or 2 ppm ozone for 2 h. Similar rates of distribution of salicylic acid in plasma and to the lungs were observed among air control animals of all age groups. Levels of 2,3-DHBA were about twice as high in the lungs of air control senescent rats compared with juvenile and adult rats (P < 0.05). Exposure to ozone resulted in 1.5- to 2-fold elevation of 2,3-DHBA in lungs and plasma of all age groups (P < 0.05), whereas levels of 2,5-DHBA were not changed significantly. There was no effect of age on the magnitude of 2,3-DHBA increase in the lungs or plasma after ozone exposure. The postulated source of OH is chemical reduction of H2O2, which could be generated from increased age-dependent endogenous oxidant production or the age-independent reaction of ozone or macrophage-derived oxidants with the surfactant lining.
引用
收藏
页码:L995 / L1003
页数:9
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