A role for the cortex in sleep-wake regulation

被引：81

作者：

Krone, Lukas B. ^{[1
,2
]}

Yamagata, Tomoko ^{[2
,3
]}

Blanco-Duque, Cristina ^{[1
,2
,4
]}

Guillaumin, Mathilde C. C. ^{[2
,3
,5
]}

Kahn, Martin C. ^{[1
,2
,4
]}

van der Vinne, Vincent ^{[1
,2
,6
]}

McKillop, Laura E. ^{[1
,2
]}

Tam, Shu K. E. ^{[2
,3
]}

Peirson, Stuart N. ^{[2
,3
]}

Akerman, Colin J. ^{[7
]}

Hoerder-Suabedissen, Anna ^{[1
]}

Molnar, Zoltan ^{[1
]}

Vyazovskiy, Vladyslav V. ^{[1
,2
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

[2] Univ Oxford, Sleep & Circadian Neurosci Inst, Oxford, England

[3] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[4] MIT, Picower Inst Learning & Memory, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] ETH, Dept Hlth Sci & Technol, Inst Neurosci, Zurich, Switzerland

[6] Williams Coll, Dept Biol, Williamstown, MA 01267 USA

[7] Univ Oxford, Dept Pharmacol, Oxford, England

来源：

NATURE NEUROSCIENCE | 2021年 / 24卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

LOCAL SLOW WAVES; REM-SLEEP; EEG; DEPRIVATION; DYNAMICS; NETWORK; CONNECTIVITY; MECHANISMS; ABSENCE; ORIGIN;

D O I：

10.1038/s41593-021-00894-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The conventional view is that the cortex generates brain oscillations, while subcortical structures control global sleep-wake switching. This study shows that the cortex plays an important role in both global state control and sleep homeostasis. Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.

引用

页码：1210 / 1215

页数：6

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