Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM

被引：21

作者：

Ahmed, Marwan A. ^{[1
]}

Muntingh, George L. ^{[1
]}

Rheeder, Paul ^{[2
]}

机构：

[1] Univ Pretoria, Fac Hlth Sci, Dept Pharmacol, Pretoria, South Africa

[2] Univ Pretoria, Steve Biko Acad Hosp, Dept Internal Med, Pretoria, South Africa

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2017年 / 2017卷

关键词：

TYPE-2; DIABETES-MELLITUS; RACIAL-DIFFERENCES; COBALAMIN STATUS; HOMOCYSTEINE; PREVALENCE; ASSOCIATION; FOLATE; RISK; HYPERHOMOCYSTEINEMIA; HEALTH;

D O I：

10.1155/2017/2452853

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.

引用

页数：6

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