Valproate-induced Fanconi Syndrome in a 27-Year-old Woman

被引：10

作者：

Patel, Sandeep M. ^{[1
]}

Graff-Radford, Jonathan ^{[2
]}

Wieland, Mark L. ^{[1
]}

机构：

[1] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

来源：

JOURNAL OF GENERAL INTERNAL MEDICINE | 2011年 / 26卷 / 09期

关键词：

valproic acid; valproate; Fanconi syndrome; adult; RENAL TUBULAR DYSFUNCTION; ACID THERAPY; CARNITINE;

D O I：

10.1007/s11606-011-1708-7

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Valproate-induced Fanconi Syndrome (VFS) is a rare complication of this therapy that has been previously described only in children with epilepsy. We report the first known case of an adult with VFS. Metabolic derangements lead patients to present with fatigue, confusion, weakness, and even bone fractures. Identification and discontinuation of the offending agent is the treatment of choice and helps confirm the diagnosis. This case highlights the importance of surveillance for metabolic derangements among patients on long term therapy with this commonly prescribed medication.

引用

页码：1072 / 1074

页数：3

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