Preterm birth alters neonatal, functional rich club organization

被引：59
|
作者：
Scheinost, Dustin [1 ]
Kwon, Soo Hyun [2 ]
Shen, Xilin [1 ]
Lacadie, Cheryl [1 ]
Schneider, Karen C. [2 ]
Dai, Feng [3 ]
Ment, Laura R. [2 ,4 ]
Constable, R. Todd [1 ,5 ]
机构：
[1] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA
[3] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA
[4] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA
[5] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT USA
来源：
BRAIN STRUCTURE & FUNCTION | 2016年 / 221卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Rich club; Network theory; Preterm birth; Connectivity; Neonate; BRAIN NETWORKS; CONNECTIVITY; LANGUAGE; CHILDREN; GROWTH; BORN; HUBS;
D O I：
10.1007/s00429-015-1096-6
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Alterations in neural networks are associated with the cognitive difficulties of the prematurely born. Using functional magnetic resonance imaging, we analyzed functional connectivity for preterm (PT) and term neonates at term equivalent age. Specifically, we constructed wholebrain networks and examined rich club (RC) organization, a common construct among complex systems where important (or "rich'') nodes connect preferentially to other important nodes. Both PT and term neonates showed RC organization with PT neonates exhibiting significantly reduced connections between these RC nodes. Additionally, PT neonates showed evidence of weaker functional segregation. Our results suggest that PT birth is associated with fundamental changes of functional organization in the developing brain.
引用
收藏
页码：3211 / 3222
页数：12
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