Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms - ex-vivo pilot study

被引：0
|
作者：
Vuong, Barry [1 ]
Sun, Cuiru [1 ]
Khiel, Tim-Rasmus [2 ]
Gardecki, Joseph A. [3 ,4 ,5 ]
Standish, Beau A. [1 ]
da Costa, Leodante [6 ,7 ]
de Morais, Josaphat [8 ]
Tearney, Guillermo J. [3 ,4 ,9 ,10 ]
Yang, Victor X. D. [1 ,7 ]
机构：
[1] Ryerson Univ, Biophoton & Bioengn Lab, Toronto, ON, Canada
[2] Univ Hlth Network, Neuropathol, Toronto, ON, Canada
[3] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA USA
[5] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA
[6] Sunnybrook Hlth Sci Ctr, Neurosurg, Toronto, ON, Canada
[7] Univ Toronto, Div Neurosurg, Toronto, ON, Canada
[8] Hosp Baleia, Neurosurg, Belo Horizonte, MG, Brazil
[9] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[10] Harvard MIT Hlth Sci & Technol, Cambridge, MA USA
来源：
PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2 | 2012年 / 8207卷
关键词：
Optical Coherence Tomography; Intracranial Aneurysm; Optical Fourier Domain Imaging; Ruptured Aneurysm; Tissue Handling; Tissue Registration; CEREBRAL ANEURYSMS; ANGIOGRAPHY; RESOLUTION; PLAQUES;
D O I：
10.1117/12.908998
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Rupture of intracranial aneurysm is a common cause of subarachnoid hemorrhage. An aneurysm may undergo microscopic morphological changes or remodeling of the vessel wall prior to rupture, which could potentially be imaged. In this study we present methods of tissue sample preparation of intracranial aneurysms and correlation between optical coherence tomography imaging and routine histology. OCT has a potential future in the assessment of microscopic features of aneurysms, which may correlate to the risk of rupture.
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页数：8
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