Pharmacokinetic curve fitting using numerical inverse Laplace transformation

被引：15

作者：

Schalla, M ^{[1
]}

Weiss, M ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Dept Pharmacol, Sect Pharmacokinet, D-06097 Halle, Germany

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 1999年 / 7卷 / 04期

关键词：

numerical Laplace transformation; Talbot's method; pharmacokinetic curve fitting;

D O I：

10.1016/S0928-0987(98)00042-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The combination of the nonlinear regression program ADAPT II with Talbot's method of numerical Laplace transformation. that allows parameter estimation when the model function is given only in the Laplace domain, is described and successfully applied to pharmacokinetic problems. The accuracy and precision of the method has been found satisfactory; its performance is comparable to that achieved in parameter estimation based on functions defined in the time domain. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：305 / 309

页数：5

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