Methylglyoxal as a scavenger for superoxide anion-radical

Methylglyoxal at a concentration of 5 mM caused a significant inhibition of superoxide anion radical (O-2 (center dot-)) comparable to the effect of Tirone. In the process of O-2 (center dot-) generation in the system of egg phosphatidylcholine liposome peroxidation induced by the azo-initiator AIBN, a marked inhibition of chemiluminescence in the presence of 100 mM methylglyoxal was found. At the same time, methylglyoxal did not inhibit free radical peroxidation of low-density lipoprotein particles, which indicates the absence of interaction with methylglyoxal alkoxyl and peroxyl polyenoic lipid radicals. These findings deepen information about the role of methylglyoxal in the regulation of free radical processes.