Methylglyoxal as a scavenger for superoxide anion-radical

被引：0
|
作者：
Shumaev, K. B. [1 ]
Lankin, V. Z. [2 ]
Konovalova, G. G. [2 ]
Grechnikova, M. A. [2 ]
Tikhaze, A. K. [2 ]
机构：
[1] Russian Acad Sci, Bach Inst Biochem, Fed Res Ctr Fundamentals Biotechnol, Leninskii Pr 33, Moscow 119071, Russia
[2] Minist Publ Hlth Russian Federat, Russian Cardiol Res & Prod Assoc, 3 Ya Cherepkovskaya Ul 15a, Moscow 121552, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 469卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
L-LYSINE; MECHANISM;
D O I：
10.1134/S1607672916040189
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Methylglyoxal at a concentration of 5 mM caused a significant inhibition of superoxide anion radical (O-2 (center dot-)) comparable to the effect of Tirone. In the process of O-2 (center dot-) generation in the system of egg phosphatidylcholine liposome peroxidation induced by the azo-initiator AIBN, a marked inhibition of chemiluminescence in the presence of 100 mM methylglyoxal was found. At the same time, methylglyoxal did not inhibit free radical peroxidation of low-density lipoprotein particles, which indicates the absence of interaction with methylglyoxal alkoxyl and peroxyl polyenoic lipid radicals. These findings deepen information about the role of methylglyoxal in the regulation of free radical processes.
引用
收藏
页码：305 / 308
页数：4
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