An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

被引：48
|
作者：
Long, Shaobo [1 ]
Chen, Lin [1 ]
Xiang, Yumi [1 ]
Song, Minggui [1 ]
Zheng, Yuguo [1 ]
Zhu, Qing [1 ]
机构：
[1] Zhejiang Univ Technol, Inst Bioengn, Hangzhou, Zhejiang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 57期
关键词：
MAO-B; ASSAYS;
D O I：
10.1039/c2cc33089j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the design and synthesis of a new class of fluorogenic probes based on monoamine oxidase-triggered oxidative C-O bond cleavage. The selectivity of probe P1 towards MAO-B was 22-fold higher than that towards MAO-A.
引用
收藏
页码：7164 / 7166
页数：3
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