Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE

被引：30

作者：

Raimondo, Joseph V. ^{[1
]}

Heinemann, Uwe ^{[2
]}

de Curtis, Marco ^{[3
]}

Goodkin, Howard P. ^{[4
,5
]}

Dulla, Chris G. ^{[6
]}

Janigro, Damir ^{[7
,8
]}

Ikeda, Akio ^{[9
]}

Lin, Chou-Ching K. ^{[10
]}

Jiruska, Premysl ^{[11
]}

Galanopoulou, Aristea S. ^{[12
]}

Bernard, Christophe ^{[13
]}

机构：

[1] Univ Cape Town, Neurosci Inst, Dept Human Biol, Div Cell Biol, Cape Town, South Africa

[2] Charite Univ Med Berlin, Neurosci Res Ctr, Berlin, Germany

[3] Fdn Carlo Besta Neurol Inst, Epilepsy & Expt Neurophysiol Unit, Milan, Italy

[4] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[5] Univ Virginia, Dept Pediat, Charlottesville, VA USA

[6] Tufts Univ, Sch Med, Dept Neurosci, Boston, MA 02111 USA

[7] Flocel Inc, Cleveland, OH USA

[8] Case Western Reserve Univ, Cleveland, OH 44106 USA

[9] Kyoto Univ, Dept Epilepsy Movement Disorders & Physiol, Grad Sch Med, Sakyo Ku, Kyoto, Japan

[10] Natl Cheng Kung Univ, Coll Med & Hosp, Dept Neurol, Tainan, Taiwan

[11] Czech Acad Sci, Inst Physiol, Dept Dev Epileptol, Prague, Czech Republic

[12] Montefiore Med Ctr, Albert Einstein Coll Med, Saul R Korey Dept Neurol,Einstein Montefiore Epil, Lab Dev Epilepsy,Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA

[13] Aix Marseille Univ, INSERM, Inst Neurosci Syst, UMRS 1106, Marseille, France

来源：

EPILEPSIA | 2017年 / 58卷

关键词：

Brain slice preparation; Electrophysiological recording methods; Recording solution composition; In vitro models of seizures; Animal selection and killing; HIPPOCAMPAL SLICE CULTURES; LONG-TERM POTENTIATION; RAT-BRAIN-SLICES; CA1 PYRAMIDAL NEURONS; NETWORK ACTIVITY; PATCH-CLAMP; POSTICTAL REFRACTORINESS; SYNAPTIC-TRANSMISSION; PROTON MODULATION; GABA(A) RECEPTORS;

D O I：

10.1111/epi.13901

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous invitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.

引用

页码：40 / 52

页数：13

共 18 条

[11] A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3-WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force
Katsarou, Anna-Maria
Kubova, Hana
Auvin, Stephane
Mantegazza, Massimo
Barker-Haliski, Melissa
Galanopoulou, Aristea S.
Reid, Christopher A.
Semple, Bridgette D.
EPILEPSIA OPEN, 2022,
[12] Can in vitro studies aid in the development and use of antiseizure therapies? A report of the ILAE/AES Joint Translational Task Force
Morris, Gareth
Avoli, Massimo
Bernard, Christophe
Connor, Kate
de Curtis, Marco
Dulla, Chris G.
Jefferys, John G. R.
Psarropoulou, Caterina
Staley, Kevin J.
Cunningham, Mark O.
EPILEPSIA, 2023, 64 (10) : 2571 - 2585
[13] A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3-WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force
Mantegazza, Massimo
Auvin, Stephane
Barker-Haliski, Melissa
Katsarou, Anna-Maria
Kubova, Hana
Galanopoulou, Aristea S.
Semple, Bridgette
Reid, Christopher A.
EPILEPSIA OPEN, 2022,
[14] A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force
van Vliet, Erwin A.
Hildebrand, Michael S.
Mills, James D.
Brennan, Gary P.
Eid, Tore
Masino, Susan A.
Whittemore, Vicky
Bindila, Laura
Wang, Kevin K.
Patel, Manisha
Perucca, Piero
Reid, Christopher A.
EPILEPSIA OPEN, 2022,
[15] A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force
Bindila, Laura
Eid, Tore
Mills, James D.
Hildebrand, Michael S.
Brennan, Gary P.
Masino, Susan A.
Whittemore, Vicky
Perucca, Piero
Reid, Christopher A.
Patel, Manisha
Wang, Kevin K.
van Vliet, Erwin A.
EPILEPSIA OPEN, 2022,
[16] A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force
Aronica, Eleonora
Binder, Devin K.
Drexel, Meinrad
Ikonomidou, Chrysanthy
Kadam, Shilpa D.
Sperk, Guenther
Steinhaeuser, Christian
EPILEPSIA OPEN, 2022,
[17] A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force
van Vliet, Erwin A.
Immonen, Riikka
Prager, Ofer
Friedman, Alon
Bankstahl, Jens P.
Wright, David K.
O'Brien, Terence J.
Potschka, Heidrun
Grohn, Olli
Harris, Neil G.
EPILEPSIA OPEN, 2022,
[18] Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3-WG1A General Pharmacology Working Group of the ILAE/AES Joint Translational Task Force
Coles, Lisa
Forcelli, Patrick A.
Leclercq, Karine
Katsarou, Anna-Maria
Klein, Brian D.
Potschka, Heidrun
Koehling, Rudiger
Harte-Hargrove, Lauren
Galanopoulou, Aristea S.
Metcalf, Cameron S.
EPILEPSIA OPEN, 2023,

← 1 2 →