EPIMHC: a curated database of MHC-binding peptides for customized computational vaccinology

被引：64
|
作者：
Reche, PA
Zhang, H
Glutting, JP
Reinherz, EL
机构：
[1] Dana Farber Canc Inst, Immunobiol Lab, Boston, MA 02115 USA
[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
来源：
BIOINFORMATICS | 2005年 / 21卷 / 09期
关键词：
D O I：
10.1093/bioinformatics/bti269
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens. The EPIMHC database is accessible through a web server that has been designed to facilitate research in computational vaccinology. Importantly, peptides resulting from a query can be selected to derive specific motif-matrices. Subsequently, these motif-matrices can be used in combination with a dynamic algorithm for predicting MHC-binding peptides from user-provided protein queries.
引用
收藏
页码：2140 / 2141
页数：2
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