Effects of age and weaning on the immature rat uterotrophic assay using ethynylestradiol

被引：2

作者：

Yamasaki, K ^{[1
]}

Sawaki, M ^{[1
]}

Noda, S ^{[1
]}

Takatuki, M ^{[1
]}

机构：

[1] Chem Assessment Ctr, Chem Evaluat & Res Inst, Oita 0870061, Japan

来源：

EXPERIMENTAL ANIMALS | 2001年 / 50卷 / 01期

关键词：

age; uterotrophic assay; weaning;

D O I：

10.1538/expanim.50.87

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The purpose of this study was to evaluate the most appropriate rat age for the start of administration, and the effect of weaning, in the immature rat uterotrophic assay using ethynylestradiol (EE). Animals weaned on postnatal day (PND) 20 were administered subcutaneously EE at doses of 0.06-6 mug/kg/day for 3 days beginning on PND 21, 23 or 25. EE at the same doses was also administered to rats weaned on PND 17 or 20 from PND 21 for 3 days. Although uterine weight was significantly increased in the rats given 0.6-6 mug/kg EE in both of the studies, the percentage increase relative to the control in each group given EE from PND 21 and weaned on PND 20 was higher than in those groups given EE from PND 23 or 25, and the group weaned on PND 17.

引用

页码：87 / 89

页数：3

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