Redefining intestinal immunity with single-cell transcriptomics

被引：15
|
作者：
James, Kylie Renee [1 ,2 ]
Elmentaite, Rasa [3 ]
Teichmann, Sarah Amalia [3 ,4 ]
Hold, Georgina Louise [5 ]
机构：
[1] Garvan Inst Med Res, Garvan Weizmann Ctr Cellular Genom, Sydney, NSW 2010, Australia
[2] Univ New South Wales, Sch Med Sci, Sydney, NSW 2006, Australia
[3] Wellcome Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
[4] Univ Cambridge, Cavendish Lab, Theory Condensed Matter Grp, Dept Phys, Cambridge CB3 0HE, England
[5] Univ New South Wales, Microbiome Res Ctr, Sydney, NSW 2217, Australia
来源：
MUCOSAL IMMUNOLOGY | 2022年 / 15卷 / 04期
关键词：
INNATE LYMPHOID-CELLS; RNA-SEQ; GENE-EXPRESSION; STROMAL CELLS; RECONSTRUCTION; HETEROGENEITY; RESPONSES; SYSTEM; HEALTH;
D O I：
10.1038/s41385-021-00470-y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The intestinal immune system represents the largest collection of immune cells in the body and is continually exposed to antigens from food and the microbiota. Here we discuss the contribution of single-cell transcriptomics in shaping our understanding of this complex system. We consider the impact on resolving early intestine development, engagement with the neighbouring microbiota, diversity of intestinal immune cells, compartmentalisation within the intestines and interactions with non-immune cells. Finally, we offer a perspective on open questions about gut immunity that evolving single-cell technologies are well placed to address.
引用
收藏
页码：531 / 541
页数：11
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