[89Zr]Zr-ImmunoPET to evaluate the efficacy of cleavable linkers in antibody drug conjugates

被引:0
|
作者
Garcia, M. Dominguez [1 ]
Raheem, S. J. [1 ]
Sharpe, J. C. [1 ]
Toosi, B. M. [1 ]
Phenix, C. P. [1 ]
Price, E. W. [1 ]
机构
[1] Univ Saskatchewan, Saskatoon, SK, Canada
关键词
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
OP-882
引用
收藏
页码:S283 / S283
页数:1
相关论文
共 50 条
  • [41] Radiation dosimetry and efficacy of an 89Zr/225Ac-labeled humanized anti-MUC5AC antibody
    Nakata, Norihito
    Kobashi, Nobuya
    Okumura, Yuki
    Sato, Mikiko
    Matono, Mitsuhiro
    Otsuki, Kumiko
    Tanaka, Akihiro
    Hayashi, Akio
    NUCLEAR MEDICINE AND BIOLOGY, 2022, 108 : 33 - 43
  • [42] Dose Reduction for 89Zr ImmunoPET Imaging Using LAFOV PET/CT: An Analysis Based on Count-Reduced Images
    Mohr, P.
    van Sluis, J.
    Providencia, L.
    Lammertsma, A. A.
    Brouwers, A. H.
    Tsoumpas, C.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 50 (SUPPL 1) : S479 - S480
  • [43] 89Zr for antibody labeling and in vivo studies - A comparison between liquid and solid target production
    Dias, Gemma M.
    Ramogida, Caterina F.
    Rousseau, Julie
    Zacchia, Nicholas A.
    Hoehr, Cornelia
    Schaffer, Paul
    Lin, Vuo Shyan
    Benard, Francois
    NUCLEAR MEDICINE AND BIOLOGY, 2018, 58 : 1 - 7
  • [44] Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers
    Salomon, Paulin L.
    Reid, Emily E.
    Archer, Katie E.
    Harris, Luke
    Maloney, Erin K.
    Wilhelm, Alan J.
    Miller, Michael L.
    Chari, Ravi V. J.
    Keating, Thomas A.
    Singh, Rajeeva
    MOLECULAR PHARMACEUTICS, 2019, 16 (12) : 4817 - 4825
  • [45] Optimizing lysosomal activation of antibody-drug conjugates (ADCs) by incorporation of novel cleavable dipeptide linkers
    Salomon, Paulin
    Harris, Luke
    Reid, Emily E.
    Maloney, Erin K.
    Wilhelm, Alan J.
    Miller, Michael L.
    Chari, Ravi V.
    Keating, Thomas A.
    Singh, Rajeeva
    CANCER RESEARCH, 2019, 79 (13)
  • [46] Preclinical evaluation of [89Zr]Zr-DFO*-sacituzumab, a PET tracer for imaging of whole body TROP-2 expression as a potential selection tool for treatment with TROP-2 antibody drug conjugates (ADC)
    Bratteby, Klas
    Smertinaite, Lidija
    Omer, Samar
    Lu, Li
    Milton, Stefan
    Jussing, Emma
    Siikanen, Jonathan
    Samen, Erik
    Axelsson, Rimma
    Foukakis, Theodoros
    Altena, Renske
    Tran, Thuy
    NUCLEAR MEDICINE AND BIOLOGY, 2023, 126 : S46 - S46
  • [47] ImmunoPET imaging of 89Zr-labeled antiTrop2 monoclonal antibody in lung cancer models
    Lu, Z.
    Shi, M.
    Li, S.
    Liang, Y.
    Zou, Z.
    Zhou, Y.
    Li, X.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2024, 51 : S819 - S819
  • [48] CYCLOTRON-DERIVED LONG-LIVED RADIOMETAL PET ISOTOPE 89ZR: CONJUGATION TO TRASTUZUMAB FOR PRECLINICAL IMMUNOPET IMAGING STUDIES
    Price, R.
    Scharli, R.
    Chan, S.
    Jeffery, C.
    Asad, A.
    Morandeau, L.
    INTERNAL MEDICINE JOURNAL, 2012, 42 : 47 - 48
  • [49] Discovery of novel cleavable linkers for site-specific antibody drug conjugates containing non oncology payloads
    Kern, Jeffrey
    Garbaccio, Robert
    Cancilla, Mark
    Dooney, Deborah
    Kwasnjuk, Kristen
    Zhang, Rena
    Antonenko, Svetlana
    Beaumont, Maribel
    Figueroa, Isabel
    Hsieh, SuChun
    Liang, Linda
    Tomazela, Daniela
    Zhang, Jeffrey
    Zhang, Shuli
    Zhang, Yiwei
    Brandish, Philip
    Palmieri, Anthony
    Stivers, Peter
    Cheng, Mangeng
    Feng, Guo
    Geda, Prasanthi
    Shah, Sanjiv
    Beck, Andrew
    Breeson, Damien
    Firdos, Johi
    Gately, Dennis
    Knudsen, Nick
    Manibusan, Anthony
    Sun, Ying
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [50] ImmunoPET and near-infrared fluorescence imaging of CD105 expression using a monoclonal antibody dual-labeled with 89Zr and IRDye 800CW
    Zhang, Yin
    Hong, Hao
    Severin, Gregory W.
    Engle, Jonathan W.
    Yang, Yunan
    Goel, Shreya
    Nathanson, Alex J.
    Liu, Glenn
    Nickles, Robert J.
    Leigh, Bryan R.
    Barnhart, Todd E.
    Cai, Weibo
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2012, 4 (03): : 333 - 346