From transformation to chronification of migraine: pathophysiological and clinical aspects

被引：79

作者：

Torres-Ferrus, M. ^{[1
]}

Ursitti, F. ^{[2
]}

Alpuente-Ruiz, A. ^{[1
]}

Brunello, F. ^{[3
]}

Chiappino, D. ^{[4
]}

de Vries, T. ^{[5
]}

Di Marco, S. ^{[6
]}

Ferlisi, S. ^{[6
]}

Guerritore, L. ^{[4
]}

Gonzalez-Garcia, N. ^{[7
]}

Gonzalez-Martinez, A. ^{[8
,9
]}

Khutorov, D. ^{[10
]}

Kritsilis, M. ^{[11
]}

Kyrou, A. ^{[12
]}

Makeeva, T. ^{[13
]}

Minguez-Olaondo, A. ^{[14
,15
,16
]}

Pilati, L. ^{[6
]}

Serrien, A. ^{[17
]}

Tsurkalenko, O. ^{[18
]}

Van den Abbeele, D. ^{[19
]}

van Hoogstraten, W. S. ^{[20
]}

Lampl, C. ^{[21
]}

机构：

[1] Univ Autonoma Barcelona, Headache & Craniofacial Pain Unit, Vall dHebron Res Inst VHIR,Dept Med, Hosp Univ Vall dHebron,Neurol Dept,Headache & Neu, Barcelona, Spain

[2] Bambino Gesu Pediat Hosp, Headache Ctr, Child Neurol Unit, Rome, Italy

[3] Univ Hosp Padua, Juvenile Headache Ctr, Dept Womans & Childs Hlth, Padua, Italy

[4] Univ Rome Sapienza, St Andrea Hosp, Dept Internal Med, Rome, Italy

[5] Erasmus MC, Dept Internal Med, Div Vasc Med & Pharmacol, Rotterdam, Netherlands

[6] Univ Palermo, Policlin Paolo Giaccone Hosp, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy

[7] Hosp Univ Clin San Carlos, Neurol Dept, Headache & Craniofacial Pain Unit, Madrid, Spain

[8] Univ Autonoma Madrid UAM, Hosp Univ La Princesa, Neurol Dept, Madrid, Spain

[9] Univ Autonoma Madrid UAM, Inst Invest Sanit La Princesa, Madrid, Spain

[10] Nikiforov Russian Ctr Emergency & Radiat Med EMER, Dept Clin Neurol & Sleep Med, St Petersburg, Russia

[11] Grevena Gen Hosp, Grevena, Greece

[12] Univ Bern, Univ Hosp Psychiat & Psychotherapy, Switzerland Univ Hosp Psychiat, Bern, Switzerland

[13] Med Ctr New Med Technol, Dept Neurol, Headache Unit, Voronezh, Russia

[14] Univ Hosp Donostia, Dept Neurol, San Sebastian, Spain

[15] Clin Univ Navarra, Dept Neurol, Pamplona, Spain

[16] Hosp Quironsalud Donostia, Dept Neurol, San Sebastian, Spain

[17] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

[18] State Inst Dnipropetrovsk Med Akad MOH Ukraine, Dept Neurol & Neurosurg, Dnipro, Ukraine

[19] Ghent Univ Hosp, Dept Neurol, Ghent, Belgium

[20] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands

[21] Ordensklinikum Linz Barmherzige Schwestern, Headache Med Ctr Linz, Linz, Austria

来源：

JOURNAL OF HEADACHE AND PAIN | 2020年 / 21卷 / 01期

关键词：

Chronic migraine; Transformation; Pathophysiology; Risk factors; Genetics; Biomarker; Neurophysiology; Neuroimaging; Animal models; GENOME-WIDE ASSOCIATION; GENE-RELATED PEPTIDE; BLOOD-BRAIN-BARRIER; CHRONIC DAILY HEADACHE; TUMOR-NECROSIS-FACTOR; EPISODIC MIGRAINE; SUSCEPTIBILITY LOCI; AMERICAN MIGRAINE; PERIPHERAL-BLOOD; INTERNATIONAL BURDEN;

D O I：

10.1186/s10194-020-01111-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from different perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiological, genetic, molecular, structural, functional, physiological and preclinical evidence available.

引用

页数：12

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