Calculating Critical Relative Humidity from Solubility According to Pitzer Ion Interaction Model

被引：4
|
作者：
Xiang, Chaoqun [1 ]
Wang, Yingli [1 ]
Zhan, Xiancheng [1 ]
Luo, Lin [1 ]
Li, Linli [1 ]
Li, Chengrong [1 ]
机构：
[1] Sichuan Univ, W China Sch Pharm, Key Lab Drug Targeting, Chengdu 610041, Sichuan, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 10期
基金：
中国国家自然科学基金;
关键词：
critical relative humidity; solubility; Raoult's law; Pitzer ion interaction model; OSMOTIC COEFFICIENTS; ELECTROLYTES; THERMODYNAMICS;
D O I：
10.1248/cpb.58.1366
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The solubility and the critical relative humidity (H-er) of 14 drugs and inorganic salts were determined, the relationship between the H-er and the solubility was explored theoretically, and the H-er was calculated in the light of Raoult's law and Pitzer ion interaction model from their solubility. The results indicate that the H-er values calculated by Raoult's law in high humidity (H-er > 80%) and by Pitzer ion interaction model in low humidity (H-er < 80%) are comparable to the measured ones.
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页码：1366 / 1368
页数：3
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