Neutralizing Antibodies to Hepatitis C Virus in Perinatally Infected Children Followed Up Prospectively

被引：8

作者：

Meunier, Jean-Christophe ^{[1
]}

Bukh, Jens ^{[1
,2
,3
,4
]}

Diaz, Giacomo ^{[5
]}

Tovo, Pier-Angelo ^{[6
]}

Casadei, Anna Maria ^{[7
]}

Quinti, Isabella ^{[8
]}

Iorio, Raffaele ^{[9
]}

Emerson, Suzanne ^{[1
]}

Purcell, Robert H. ^{[1
]}

Farci, Patrizia ^{[1
]}

机构：

[1] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Copenhagen Univ Hosp, Dept Infect Dis, Copenhagen Hepatitis Program CO HEP C, Hvidovre, Denmark

[3] Copenhagen Univ Hosp, Clin Res Ctr, Hvidovre, Denmark

[4] Univ Copenhagen, Fac Hlth Sci, Dept Int Hlth Immunol & Microbiol, DK-1168 Copenhagen, Denmark

[5] Univ Cagliari, Dept Biomed Sci & Technol, I-09124 Cagliari, Italy

[6] Univ Turin, Dept Pediat, I-10124 Turin, Italy

[7] Univ Roma La Sapienza, Dept Pediat, Rome, Italy

[8] Univ Roma La Sapienza, Dept Clin Med, Rome, Italy

[9] Univ Naples Federico II, Dept Pediat, Naples, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 11期

基金：

美国国家卫生研究院;

关键词：

PROGRESSION; EVOLUTION;

D O I：

10.1093/infdis/jir631

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Little is known about the presence and role of neutralizing antibodies (NtAbs) in perinatal hepatitis C virus (HCV) infection. Using HCV pseudoparticles, NtAbs were studied longitudinally in 12 HCV-infected children with or without evidence of acute hepatitis during the first year of life. Broadly reactive NtAbs of maternal origin did not prevent vertical HCV transmission or progression to chronicity. NtAbs against homologous genotype or subtype appeared during the chronic phase and were more abundant and sustained in children with acute hepatitis. Cross-reactive NtAbs were present in both groups of children, but their appearance did not correlate with better control of viremia or HCV clearance.

引用

页码：1741 / 1745

页数：5

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