Targeting the gut-liver axis in liver disease

被引：309

作者：

Wiest, Reiner ^{[1
]}

Albillos, Agustin ^{[2
]}

Trauner, Michael ^{[3
]}

Bajaj, Jasmohan S. ^{[4
,5
]}

Jalan, Rajiv ^{[6
]}

机构：

[1] Univ Hosp, Gastroenterol, CH-3010 Bern, Switzerland

[2] Hosp Univ Ramon & Cajal, Gastroenterol & Hepatol, Madrid, Spain

[3] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria

[4] Virginia Commonwealth Univ, Richmond, VA USA

[5] McGuire VA Med Ctr, GI Hepatol, Richmond, VA USA

[6] UCL, Inst Hepatol, London, England

来源：

JOURNAL OF HEPATOLOGY | 2017年 / 67卷 / 05期

基金：

欧盟地平线“2020”;

关键词：

Gut-liver-axis; Bacterial translocation; Liver injury; Fibrosis; Cirrhosis; Bile acids; Microbiome; Incretines; Pre-; probiotics; Faecal microbial transplantation; PRIMARY SCLEROSING CHOLANGITIS; NONSELECTIVE BETA-BLOCKERS; RANDOMIZED CONTROLLED-TRIAL; SECRETORY IMMUNOGLOBULIN-A; CONTROLLED CLINICAL-TRIAL; BACTERIAL TRANSLOCATION; HEPATOCELLULAR-CARCINOMA; OBETICHOLIC ACID; HEPATIC-ENCEPHALOPATHY; DOUBLE-BLIND;

D O I：

10.1016/j.jhep.2017.05.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gut-liver axis is widely implicated in the pathogenesis of liver diseases, where it is increasingly the focus of clinical research. Recent studies trialling an array of therapeutic and preventative strategies have yielded promising results. Considering these strategies, the armamentarium for targeting the gut-liver axis will continue to expand. Further clinical trials, translated from our current knowledge of the gut-liver axis, promise an exciting future in liver treatment. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：1084 / 1103

页数：20

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