Anti-urolithiatic activity of hydrogenated naphthol isolated from Aerva lanata (L.) Juss. flower extract

被引：0
|
作者：
Behera, Padma Charan [1 ]
Bag, Bama Prasad [2 ]
Ghosh, Manik [1 ]
机构：
[1] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India
[2] CSIR, Inst Minerals & Mat Technol, Bhubaneswar 751013, Odisha, India
来源：
INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE | 2016年 / 15卷 / 03期
关键词：
Aerva lanata; Hydrogenated naphthol; Urolithiasis; Ethylene glycol; !text type='JAVA']JAVA[!/text]NICA;
D O I：
暂无
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
One new hydrogenated naphthol was isolated for the first time from methanolic extract of Aerva lanata (L.) Juss. flowers. The compound was elucidated as (2S.3R) 3-(3-hydroxy-3-methyl pent-4-en-1-y1)-2, 5, 5, 8a tetra-methyldecahydronaphthalene-2-ol. The isolated compound (PC) was screened for anti-urolithiatic activity by ethylene glycol induced urolithiasis in rats. In the present study rats treated with the isolated compound (PC), reported for the first time from this taxon, reduced the deposition of calcium oxalate crystals by increasing their solubility and restoring the normal renal architecture.
引用
收藏
页码：453 / 459
页数：7
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