Regioselective Nickel-Catalyzed Reductive Couplings of Enones and Allenes

被引：22
|
作者：
Li, Wei [1 ]
Chen, Nan [1 ]
Montgomery, John [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 46期
基金：
美国国家科学基金会;
关键词：
allenes; conjugate addition; nickel; reductive coupling; regioselectivity; TRANSFER HYDROGENATION; STEREOSELECTIVE-SYNTHESIS; 2-COMPONENT ADDITION; REVERSE PRENYLATION; CONJUGATE ADDITION; CARBONYL-COMPOUNDS; FORM 1,3-DIENES; SIMPLE ALKENES; ALKYNES; CYCLIZATIONS;
D O I：
10.1002/anie.201004740
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Alkenes made easy: In a complement to coupling processes of terminal alkynes, the reductive coupling of enones and allenes provides access to conjugate addition products that possess a 1,1-disubstituted alkene (see scheme; cod=1,5-cyclooctadiene). The solvent composition and reducing agent must be carefully matched to allow high levels of regioselectivity to be observed. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8712 / 8716
页数：5
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