Preparation and Regulating Cell Adhesion of Anion-Exchangeable. Layered Double Hydroxide Micropatterned Arrays

被引：25
|
作者：
Yao, Feng [1 ]
Hu, Hao [1 ]
Xu, Sailong [1 ]
Huo, Ruijie [1 ]
Zhao, Zhiping [1 ]
Zhang, Fazhi [1 ]
Xu, Fujian [1 ,2 ,3 ]
机构：
[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
[2] Beijing Univ Chem Technol, Key Lab Carbon Fiber & Funct Polymers, Minist Educ, Coll Mat Sci & Engn, Beijing 100029, Peoples R China
[3] Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 07期
基金：
中国国家自然科学基金;
关键词：
layered double hydroxide; micropatterned arrays; photolithography; in situ growth; cell adhesion; methotrexate; DRUG-DELIVERY; INORGANIC NANOVEHICLE; INTERCALATION; NANOPARTICLES; NANOHYBRIDS; HYDROGEL; RELEASE; TUMOR; DNA;
D O I：
10.1021/acsami.5b00145
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We describe a reliable preparation of MgAl-layered double hydroxide (MgAl-LDH) micropatterned arrays on gold substrate by combining SO3- -terminated self-assembly monolayer and photolithography. The synthesis route is readily extended to prepare LDH arrays on the SO3- -terminated polymer-bonded glass substrate amenable for cell imaging. The anion-exchangeable MgAl-LDH micropattern can act both as bioadhesive region for selective cell adhesion and as nanocarrier for drug molecules to regulate cell behaviors. Quantitative analysis of cell adhesion shows that selective HepG2 cell adhesion and spreading are promoted by the micropatterned MgAl-LDH, and also suppressed by methotrexate drug released from the LDH interlayer galleries.
引用
收藏
页码：3882 / 3887
页数：6
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