Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

被引：218
|
作者：
Li, Xiaozhen [1 ]
Liu, Lu [2 ]
Li, Shengliang [1 ]
Wan, Yingpeng [1 ]
Chen, Jia-Xiong [1 ,4 ]
Tian, Shuang [1 ]
Huang, Zhongming [1 ]
Xiao, Ya-Fang [1 ]
Cui, Xiao [1 ]
Xiang, Chengyan [3 ]
Tan, Qinglong [3 ]
Zhang, Xiao-Hong [4 ]
Guo, Weisheng [3 ]
Liang, Xing-Jie [2 ]
Lee, Chun-Sing [1 ]
机构：
[1] City Univ Hong Kong, Dept Chem, COSDAF, Kowloon, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China
[2] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, 11 First North Rd, Beijing 100190, Peoples R China
[3] Guangzhou Med Univ, Affiliated Hosp 2, State Key Lab Resp Dis, Translat Med Ctr, Guangzhou 510260, Guangdong, Peoples R China
[4] Soochow Univ, Joint Int Res Lab Carbon Based Funct Mat & Device, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China
来源：
ACS NANO | 2019年 / 13卷 / 11期
关键词：
conjugated oligomer; nanoparticle; photothermal conversion efficiency; biodegradability; photothermal therapy; SEMICONDUCTING POLYMER NANOPARTICLES; CARBON NANOTUBES; THERAPY; NANOMATERIALS; ACTIVATION; GRAPHENE; OXIDE; DOTS;
D O I：
10.1021/acsnano.9b05383
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We developed a biodegradable photothermal therapeutic (PTT) agent, pi-conjugated oligomer nanoparticles (F8 -PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent nearinfrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8 -PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.
引用
收藏
页码：12901 / 12911
页数：11
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