A simple procedure for the synthesis of γ-hydroxy-α,β-(E)-alkenoic esters:: formal synthesis of (+)-macrosphelides A and B

被引：17
|
作者：
Rao, KS
Mukkanti, K
Reddy, DS
Pal, M
Lqbal, J
机构：
[1] Dr Reddys Labs Ltd, Discovery Res, Hyderabad 500049, Andhra Pradesh, India
[2] JNT Univ, Inst Sci & Technol, Div Chem, Hyderabad 500072, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 13期
关键词：
conjugate reduction; gamma-hydroxy-alpha; beta-alkenoic esters; macrosphelide;
D O I：
10.1016/j.tetlet.2005.02.004
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly trans-selective conjugate reduction of 7-hydroxy-alpha,beta-alkynoic esters to produce gamma-hydroxy-alpha,beta-(E)-alkenoic esters using LiAlH4 is reported. The application of this methodology is demonstrated by a formal synthesis of the potent cell-cell adhesion inhibitors (+)-macrosphelides A and B. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2287 / 2290
页数：4
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