Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

被引：5

作者：

Moia, Riccardo ^{[1
,2
]}

Cittone, Micol Giulia ^{[2
,3
]}

Boggione, Paola ^{[1
,2
]}

Manfredi, Giulia Francesca ^{[2
,3
]}

Favini, Chiara ^{[1
,2
]}

Awikeh, Bassel ^{[1
,2
]}

Pedrinelli, Anita Rebecca ^{[2
,3
]}

Mahmoud, Abdurraouf Mokhtar ^{[1
,2
]}

Nicolosi, Maura ^{[1
,2
]}

Bellan, Mattia ^{[2
,3
]}

Sainaghi, Pier Paolo ^{[2
,3
]}

Pirisi, Mario ^{[2
,3
]}

Gaidano, Gianluca ^{[1
,2
]}

Patriarca, Andrea ^{[1
,2
]}

Rigamonti, Cristina ^{[2
,3
]}

机构：

[1] Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy

[2] Azienda Osped Univ Maggiore Carita, Novara, Italy

[3] Univ Piemonte Orientale, Dept Translat Med, Div Internal Med, Novara, Italy

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

myeloproliferative neoplasms; spleen stiffness; JAK2; mutations; vibration-controlled transient elastography (VCTE); NGS; TRANSIENT ELASTOGRAPHY; PORTAL-HYPERTENSION; STIFFNESS; LIVER;

D O I：

10.3389/fonc.2021.777730

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells >= 10,000/mu l (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.

引用

页数：5

共 50 条

[31] Associations of JAK2 Mutant Allele Burden With Occurrence of CKD (Chronic Kidney Disease) and Dynamics of Kidney Function Over Time in Patients With Chronic Myeloproliferative Neoplasms
Lucijanic, Marko
Veic, Petra
Aric, Ivona
Tupek, Katarina Marija
Soric, Ena
Sabljic, Anica
Glasnovic, Josipa Vlasac
Stoos-Veic, Tajana
Krecak, Ivan
Kusec, Rajko
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S394 - S394
[32] The implication of identifying JAK2V617F in myeloproliferative neoplasms and myelodysplastic syndromes with bone marrow fibrosis
Olsen R.J.
Dunphy C.H.
O'Malley D.P.
Rice L.
Ewton A.A.
Chang C.-C.
Journal of Hematopathology, 2008, 1 (2) : 111 - 117
[33] THE CORRELATION BETWEEN THE JAK2 ALLELE BURDEN AND HEMATOLOGIC/ CLINICAL PARAMETERS OF PHILADELPHIA-NEGATIVE MYELOPROLIFERATIVE NEOPLASIA PATIENTS
Can, E. Saribacak
Malkan, U.
Okay, M.
Albayrak, M.
Gunes, G.
LEUKEMIA RESEARCH, 2017, 61 : S24 - S25
[34] Assessing the Predictive Value of JAK2 V617F Allele Burden in Non-CML Classical Subtypes of Myeloproliferative Neoplasms
Gober-Wilcox, Julie
Vennapusa, Bharathi
Pierce, Joseph
Vasef, Mohammad A.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2009, 132 (03) : 455 - 455
[35] JAK2V617F allele burden: innovative concept in monitoring of myeloproliferative neoplasms
Bagheropur S.
Ehsanpour A.
Birgani M.T.
Saki N.
memo - Magazine of European Medical Oncology, 2018, 11 (2) : 152 - 157
[36] JAK2 p.V617F allele burden in myeloproliferative neoplasms one month after allogeneic stem cell transplantation significantly predicts outcome and risk of relapse
Lange, Thoralf
Edelmann, Anja
Siebolts, Udo
Krahl, Rainer
Nehring, Claudia
Jakel, Nadja
Cross, Michael
Maier, Jacqueline
Niederwieser, Dietger
Wickenhauser, Claudia
HAEMATOLOGICA, 2013, 98 (05) : 722 - 728
[37] JAK2 HAPLOTYPE 46/1 (GGCC) HAS NO EFFECT ON THE PRIMARY RISK OF JAK2 V617F MUTATION, BUT IT STRONGLY POTENTIATES THE PROGRESSION OF GROWN ALLELE BURDEN IN MYELOPROLIFERATIVE NEOPLASMS
Stolyar, M.
Klimova, O.
Ivanov, M.
Gorbenko, A.
Titov, S.
Olkhovskiy, I.
HAEMATOLOGICA, 2017, 102 : 539 - 539
[38] The JAK2 46/1 haplotype is a risk factor for myeloproliferative neoplasms in Chinese patients
Zhang, Xinju
Hu, Tingting
Wu, Zhiyuan
Kang, Zhihua
Liu, Weiwei
Guan, Ming
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2012, 96 (05) : 611 - 616
[39] TERT and JAK2 polymorphisms define genetic predisposition to myeloproliferative neoplasms in Japanese patients
Matsuguma, Masafumi
Yujiri, Toshiaki
Yamamoto, Kaoru
Kajimura, Yasuko
Tokunaga, Yoshihiro
Tanaka, Mayumi
Tanaka, Yoshinori
Nakamura, Yukinori
Tanizawa, Yukio
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2019, 110 (06) : 690 - 698
[40] The JAK2 46/1 haplotype is a risk factor for myeloproliferative neoplasms in Chinese patients
Xinju Zhang
Tingting Hu
Zhiyuan Wu
Zhihua Kang
Weiwei Liu
Ming Guan
International Journal of Hematology, 2012, 96 : 611 - 616

← 1 2 3 4 5 →