Disruption of perineuronal nets increases the frequency of sharp wave ripple events
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作者:
Sun, Zhi Yong
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Jilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R ChinaJilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
Sun, Zhi Yong
[1
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Bozzelli, P. Lorenzo
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机构:
Georgetown Univ, Sch Med, Dept Neurosci, Washington, DC 20057 USA
Georgetown Univ, Sch Med, Interdisciplinary Program Neurosci, Washington, DC USAJilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
Bozzelli, P. Lorenzo
[2
,3
]
Caccavano, Adam
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机构:
Georgetown Univ, Sch Med, Interdisciplinary Program Neurosci, Washington, DC USA
Georgetown Univ, Sch Med, Dept Pharmacol, Washington, DC USAJilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
Caccavano, Adam
[3
,4
]
Allen, Megan
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机构:
Georgetown Univ, Sch Med, Dept Neurosci, Washington, DC 20057 USA
Georgetown Univ, Sch Med, Interdisciplinary Program Neurosci, Washington, DC USAJilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
Allen, Megan
[2
,3
]
Balmuth, Jason
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Johns Hopkins Univ, Appl Phys Lab, Baltimore, MD 21218 USAJilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
Balmuth, Jason
[5
]
Vicini, Stefano
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Georgetown Univ, Sch Med, Interdisciplinary Program Neurosci, Washington, DC USA
Georgetown Univ, Sch Med, Dept Pharmacol, Washington, DC USAJilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
Vicini, Stefano
[3
,4
]
Wu, Jian-Young
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Georgetown Univ, Sch Med, Dept Neurosci, Washington, DC 20057 USA
Georgetown Univ, Sch Med, Interdisciplinary Program Neurosci, Washington, DC USAJilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
Wu, Jian-Young
[2
,3
]
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Conant, Katherine
[2
,3
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机构:
[1] Jilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
[2] Georgetown Univ, Sch Med, Dept Neurosci, Washington, DC 20057 USA
[3] Georgetown Univ, Sch Med, Interdisciplinary Program Neurosci, Washington, DC USA
[4] Georgetown Univ, Sch Med, Dept Pharmacol, Washington, DC USA
Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest and slow wave sleep. SWR activity that follows learning involves sequential replay of training-associated neuronal assemblies and is critical for systems level memory consolidation. SWRs are initiated by CA2 or CA3 pyramidal cells (PCs) and require initial excitation of CA1 PCs as well as participation of parvalbumin (PV) expressing fast spiking (FS) inhibitory interneurons. These interneurons are relatively unique in that they represent the major neuronal cell type known to be surrounded by perineuronal nets (PNNs), lattice like structures composed of a hyaluronin backbone that surround the cell soma and proximal dendrites. Though the function of the PNN is not completely understood, previous studies suggest it may serve to localize glutamatergic input to synaptic contacts and thus influence the activity of ensheathed cells. Noting that FS PV interneurons impact the activity of PCs thought to initiate SWRs, and that their activity is critical to ripple expression, we examine the effects of PNN integrity on SWR activity in the hippocampus. Extracellular recordings from the stratum radiatum of horizontal murine hippocampal hemisections demonstrate SWRs that occur spontaneously in CA1. As compared with vehicle, pre-treatment (120 min) of paired hemislices with hyaluronidase, which cleaves the hyaluronin backbone of the PNN, decreases PNN integrity and increases SWR frequency. Pre-treatment with chondroitinase, which cleaves PNN side chains, also increases SWR frequency. Together, these data contribute to an emerging appreciation of extracellular matrix as a regulator of neuronal plasticity and suggest that one function of mature perineuronal nets could be to modulate the frequency of SWR events.
机构:
BIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, ItalyBIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, Italy
Poli, Andrea
Viglione, Aurelia
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BIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, ItalyBIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, Italy
Viglione, Aurelia
Mazziotti, Raffaele
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CNR, Inst Neurosci, Via Moruzzi,1, I-56124 Pisa, ItalyBIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, Italy
Mazziotti, Raffaele
Totaro, Valentino
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BIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, ItalyBIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, Italy
Totaro, Valentino
Morea, Silvia
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CNR, Inst Neurosci, Via Moruzzi,1, I-56124 Pisa, ItalyBIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, Italy
Morea, Silvia
Melani, Riccardo
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机构:
New York Univ Grossman Sch Med, Neurosci Inst, New York, NY 10016 USABIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, Italy
Melani, Riccardo
Silingardi, Davide
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机构:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEUROF, I-50134 Florence, ItalyBIOSNS Lab, Scuola Normale Super Via G,Moruzzi 1, I-56124 Pisa, Italy
机构:
Univ Calif San Francisco, Med Scientist Training Program, San Francisco, CA 94143 USA
Univ Calif San Francisco, Neurosci Grad Program, San Francisco, CA 94143 USA
Univ Calif San Francisco, Ctr Integrat Neurosci, Kavli Inst Fundamental Neurosci, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Med Scientist Training Program, San Francisco, CA 94143 USA
Joo, Hannah R.
Frank, Loren M.
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Univ Calif San Francisco, Ctr Integrat Neurosci, Kavli Inst Fundamental Neurosci, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
Howard Hughes Med Inst, Chevy Chase, MD USAUniv Calif San Francisco, Med Scientist Training Program, San Francisco, CA 94143 USA
机构:
IST Austria, Klosterneuburg, AustriaIST Austria, Klosterneuburg, Austria
Kovacs, Krisztian A.
O'Neill, Joseph
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IST Austria, Klosterneuburg, AustriaIST Austria, Klosterneuburg, Austria
O'Neill, Joseph
Schoenenberger, Philipp
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IST Austria, Klosterneuburg, Austria
F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Grenzacherstr 124, CH-4070 Basel, SwitzerlandIST Austria, Klosterneuburg, Austria
Schoenenberger, Philipp
Penttonen, Markku
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Univ Jyvaskyla, Dept Psychol, Jyvaskyla, FinlandIST Austria, Klosterneuburg, Austria
Penttonen, Markku
Guerrero, Damaris K. Ranguel
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IST Austria, Klosterneuburg, AustriaIST Austria, Klosterneuburg, Austria
Guerrero, Damaris K. Ranguel
Csicsvari, Jozsef
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IST Austria, Klosterneuburg, AustriaIST Austria, Klosterneuburg, Austria