Disruption of perineuronal nets increases the frequency of sharp wave ripple events

被引:38
|
作者
Sun, Zhi Yong [1 ]
Bozzelli, P. Lorenzo [2 ,3 ]
Caccavano, Adam [3 ,4 ]
Allen, Megan [2 ,3 ]
Balmuth, Jason [5 ]
Vicini, Stefano [3 ,4 ]
Wu, Jian-Young [2 ,3 ]
Conant, Katherine [2 ,3 ]
机构
[1] Jilin Women & Childrens Hlth Hosp, Changchun, Jilin, Peoples R China
[2] Georgetown Univ, Sch Med, Dept Neurosci, Washington, DC 20057 USA
[3] Georgetown Univ, Sch Med, Interdisciplinary Program Neurosci, Washington, DC USA
[4] Georgetown Univ, Sch Med, Dept Pharmacol, Washington, DC USA
[5] Johns Hopkins Univ, Appl Phys Lab, Baltimore, MD 21218 USA
基金
美国国家卫生研究院;
关键词
chondrotinase; hippocampus; hyaluronidase; protease; PV interneuron; EXTRACELLULAR-MATRIX; HIPPOCAMPAL RIPPLES; NETWORK MECHANISMS; VISUAL-CORTEX; NMDA RECEPTOR; PLACE CELLS; PLASTICITY; MATRIX-METALLOPROTEINASE-9; EXPRESSION; IMPAIRS;
D O I
10.1002/hipo.22804
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest and slow wave sleep. SWR activity that follows learning involves sequential replay of training-associated neuronal assemblies and is critical for systems level memory consolidation. SWRs are initiated by CA2 or CA3 pyramidal cells (PCs) and require initial excitation of CA1 PCs as well as participation of parvalbumin (PV) expressing fast spiking (FS) inhibitory interneurons. These interneurons are relatively unique in that they represent the major neuronal cell type known to be surrounded by perineuronal nets (PNNs), lattice like structures composed of a hyaluronin backbone that surround the cell soma and proximal dendrites. Though the function of the PNN is not completely understood, previous studies suggest it may serve to localize glutamatergic input to synaptic contacts and thus influence the activity of ensheathed cells. Noting that FS PV interneurons impact the activity of PCs thought to initiate SWRs, and that their activity is critical to ripple expression, we examine the effects of PNN integrity on SWR activity in the hippocampus. Extracellular recordings from the stratum radiatum of horizontal murine hippocampal hemisections demonstrate SWRs that occur spontaneously in CA1. As compared with vehicle, pre-treatment (120 min) of paired hemislices with hyaluronidase, which cleaves the hyaluronin backbone of the PNN, decreases PNN integrity and increases SWR frequency. Pre-treatment with chondroitinase, which cleaves PNN side chains, also increases SWR frequency. Together, these data contribute to an emerging appreciation of extracellular matrix as a regulator of neuronal plasticity and suggest that one function of mature perineuronal nets could be to modulate the frequency of SWR events.
引用
收藏
页码:42 / 52
页数:11
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