Synthesis of bicyclic aryl thiazolines with selective anti-proliferative effects on human cancer cell lines

被引：0
|
作者：
Singh, Rakesh K. [1 ]
Lange, Thilo S. [1 ,2 ]
Kim, Kyu K. [1 ]
Singh, Ajay P. [3 ]
Hopson, Russell [4 ]
Vorsa, Nicholi [3 ]
Brard, Laurent [1 ]
机构：
[1] Brown Univ, Women & Infants Hosp, Warren Alpert Med Sch,Program Womens Oncol, Dept Obstet & Gynecol,Div Gynecol Oncol,Mol Thera, Providence, RI 02905 USA
[2] Brown Univ, Div Biol & Med, Providence, RI 02912 USA
[3] Rutgers State Univ, Dept Plant Biol, New Brunswick, NJ 08901 USA
[4] Brown Univ, Dept Chem, Providence, RI 02912 USA
来源：
LETTERS IN ORGANIC CHEMISTRY | 2008年 / 5卷 / 02期
关键词：
thiazolines; eschenmoser; cytotoxicity; neuroblastoma; ovarian cancer;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential anti-proliferative effects.
引用
收藏
页码：103 / 109
页数：7
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