Quaternized Chitosan (QCS) Nanoparticles as a Novel Delivery System for Ammonium Glycyrrhizinate

被引：7
|
作者：
Wang, Tie Wei [1 ,2 ,3 ]
Xu, Qing [1 ,2 ]
Wu, Yan [1 ,2 ]
Zeng, Ai Jun [3 ]
Li, Mingjun [4 ]
Gao, Hongxia [4 ]
机构：
[1] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[3] China Agr Univ, Beijing 100083, Peoples R China
[4] Jiamusi Univ, Affiliated Hosp 1, Jiamusi 154002, Peoples R China
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2010年 / 10卷 / 11期
关键词：
Quaternized Chitosan; Poly(Aspartic Acid); Nanoparticles; lonotropic Gelation; Ammonium Glycyrrhizinate; Delivery;
D O I：
10.1166/jnn.2010.2827
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this study was to generate a new type of nanoparticles made of quaternized chitosan (QCS) and poly(aspartic acid) via the ionotropic gelation technique and to evaluate their potential for the association and delivery of ammonium glycyrrhizinate (GLA). The effects of the pH value of nanoparticles, QCS molecular weight (Mw) and poly(aspartic acid) concentration on GLA encapsulation were studied. Suitably pH value of nanoparticles, moderate QCS MW, optimal concentration ratio of poly(aspartic acid) and QCS favored higher GLA encapsulation efficiency. The release of GLA from nanoparticles was pH-dependent. Fast release occurred in 0.1 M phosphate buffer solution (PBS, pH = 7.4), while the release was slow in 0.1 M HCI (pH = 1.2). The results showed that the new QCS/poly(aspartic acid) nanoparticles have a promising potential in GLA delivery system.
引用
收藏
页码：7402 / 7405
页数：4
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