Posterior Reversible Encephalopathy Syndrome Following Chemotherapy and Immune Checkpoint Inhibitor Combination in a Patient with Small-Cell Lung Cancer
被引:3
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作者:
Evin, Cecile
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机构:
Univ Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, FranceUniv Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, France
Evin, Cecile
[1
]
Lassau, Nathalie
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机构:
Univ Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, France
Univ Paris Saclay, CNRS, Biomaps, INSERM,CEA,UMR1281, F-94805 Villejuif, FranceUniv Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, France
Lassau, Nathalie
[1
,2
]
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Balleyguier, Corinne
[1
,2
]
Assi, Tarek
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机构:
Univ Paris Saclay, Dept Oncol, Gustave Roussy, F-94805 Villejuif, FranceUniv Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, France
Assi, Tarek
[3
]
Ammari, Samy
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机构:
Univ Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, France
Univ Paris Saclay, CNRS, Biomaps, INSERM,CEA,UMR1281, F-94805 Villejuif, FranceUniv Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, France
Ammari, Samy
[1
,2
]
机构:
[1] Univ Paris Saclay, Dept Imaging, Gustave Roussy, F-94805 Villejuif, France
[2] Univ Paris Saclay, CNRS, Biomaps, INSERM,CEA,UMR1281, F-94805 Villejuif, France
[3] Univ Paris Saclay, Dept Oncol, Gustave Roussy, F-94805 Villejuif, France
PRES;
chemotherapy;
immunotherapy;
status epilepticus;
diaschisis;
LEUKOENCEPHALOPATHY SYNDROME;
CARBOPLATIN;
IMMUNOTHERAPY;
D O I:
10.3390/diagnostics12061369
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Posterior reversible encephalopathy syndrome (PRES) is a rare neurological complication that occurs following a sudden blood pressure increase. We report the case of a 64-year-old patient presenting PRES several hours after the administration of a combination of chemotherapy and a checkpoint inhibitor (carboplatin-etoposide-atezolizumab) for small-cell lung cancer. He presented consciousness disorders associated with partial epileptic seizure secondarily generalized. His arterial blood pressure was elevated and brain imaging showed multiple bilateral subcortical parietal, temporal, occipital and cerebellar T2 high signals, predominantly in the posterior region. There were no abnormal T1 signals nor bleeding but a left apparent diffusion coefficient restriction was noted. On arterial spin labelling perfusion sequences, there was an increased perfusion within the left temporo-parieto-occipital, left thalamic and right cerebellar regions. Finally, the neurological symptoms completely regressed after several days of optimal antihypertensive and antiepileptic treatment. The clinical context and radiological features, as well as the progressive resolution of the neurological symptoms, were all in favor of PRES. PRES can occur after the administration of chemotherapy and/or immunotherapy. Prompt diagnosis is crucial through a spectrum of suspicious clinical and radiological characteristics that must be rapidly recognized to quickly anticipate the optimal therapeutic strategy and avoid unnecessary complications.
机构:
Cantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Univ Toronto, Lung Unit, Princess Margaret Canc Ctr, Toronto, ON, CanadaCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Schmid, Sabine
Mauti, Laetitia A.
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机构:
Cantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Mauti, Laetitia A.
Friedlaender, Alex
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机构:
Hop Univ Geneve, Oncol, Geneva, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Friedlaender, Alex
Blum, Veronika
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机构:
Cantonal Hosp Lucerne, Dept Oncol, Luzern, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Blum, Veronika
Rothschild, Sacha I.
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机构:
Univ Hosp Basel, Dept Oncol, Basel, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Rothschild, Sacha I.
Bouchaab, Hasna
论文数: 0引用数: 0
h-index: 0
机构:
CHU Vaudois, Oncol, Lausanne, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Bouchaab, Hasna
Frosch, Patrizia
论文数: 0引用数: 0
h-index: 0
机构:
Osped Reg Bellinzona & Valli, Ist Oncol Svizzera Italiana, Bellinzona, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Frosch, Patrizia
Britschgi, Christian
论文数: 0引用数: 0
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机构:
Univ Zurich, Comprehens Canc Ctr Zurich, Univ Hosp Zurich, Dept Med Oncol & Hematol, Zurich, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Britschgi, Christian
Konig, David
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机构:
Cantonal Hosp Winterthur, Dept Oncol, Winterthur, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Konig, David
Wannesson, Luciano
论文数: 0引用数: 0
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机构:
Osped Reg Bellinzona & Valli, Ist Oncol Svizzera Italiana, Bellinzona, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
Wannesson, Luciano
Janthur, Wolf-Dieter
论文数: 0引用数: 0
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机构:
Cantonal Hosp Aarau, Dept Oncol, Aarau, SwitzerlandCantonal Hosp St Gallen, Dept Oncol & Haematol, CH-9007 St Gallen, Switzerland
机构:
Weifang Med Univ, Dept Clin Med Coll, Weifang, Peoples R China
Shandong First Med Univ, Cent Hosp, Dept Oncol, Jinan, Peoples R ChinaWeifang Med Univ, Dept Clin Med Coll, Weifang, Peoples R China
Zou, Xiaomeng
Zhou, Peng
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机构:
Shandong First Med Univ, Cent Hosp, Dept Med Imaging Ctr, Jinan, Peoples R ChinaWeifang Med Univ, Dept Clin Med Coll, Weifang, Peoples R China
Zhou, Peng
Lv, Wei
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机构:
Shandong First Med Univ, Cent Hosp, Dept Cardiol, Jinan, Peoples R ChinaWeifang Med Univ, Dept Clin Med Coll, Weifang, Peoples R China
Lv, Wei
Liu, Chuanyong
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h-index: 0
机构:
Shandong First Med Univ, Cent Hosp, Dept Oncol, Jinan, Peoples R ChinaWeifang Med Univ, Dept Clin Med Coll, Weifang, Peoples R China
Liu, Chuanyong
Liu, Jie
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机构:
Shandong First Med Univ, Cent Hosp, Dept Oncol, Jinan, Peoples R ChinaWeifang Med Univ, Dept Clin Med Coll, Weifang, Peoples R China
机构:
Department of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,SpainDepartment of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,Spain
Jaime Ceballos-Viro
José M López-Picazo
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机构:
Department of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,SpainDepartment of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,Spain
José M López-Picazo
José L Pérez-Gracia
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机构:
Department of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,SpainDepartment of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,Spain
José L Pérez-Gracia
Jesús J Sola
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机构:
Department of Pathology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,SpainDepartment of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,Spain
Jesús J Sola
Gregorio Aisa
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机构:
Department of Pathology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,SpainDepartment of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,Spain
Gregorio Aisa
Ignacio Gil-Bazo
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机构:
Department of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,SpainDepartment of Oncology,Clínica Universidad de Navarra,Pio XII 36,31008 Pamplona,Spain