ATP in endolymph enhances electrically-evoked oto-acoustic emissions from the guinea pig cochlea

被引：18
|
作者：
Kirk, DL [1 ]
Yates, GK [1 ]
机构：
[1] Univ Western Australia, Dept Physiol, Nedlands, WA 6097, Australia
来源：
NEUROSCIENCE LETTERS | 1998年 / 250卷 / 03期
基金：
英国医学研究理事会;
关键词：
adenosine triphosphate; hair cell; cochlea; electromotility; oto-acoustic emission; iontophoresis;
D O I：
10.1016/S0304-3940(98)00460-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
ATP was iontophoresed into the scala media of the guinea pig cochlea. A reversible increase in the amplitude of electrically-evoked oto-acoustic emissions (EEOAEs), and reductions in the endocochlear potential (EP) and the cochlear microphonic (CM) were observed. These effects were consistent with an action of ATP on P-2x receptors on outer hair cells (OHC). The results confirm that endogenous endolymphatic ATP, acting via P-2x receptors on OHCs, may serve a regulatory function in the cochlea. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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页码：149 / 152
页数：4
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