Autofocusing MALDI mass spectrometry imaging of tissue sections and 3D chemical topography of nonflat surfaces

被引：102
|
作者：
Kompauer, Mario [1 ]
Heiles, Sven [1 ]
Spengler, Bernhard [1 ]
机构：
[1] Justus Liebig Univ Giessen, Inst Inorgan & Analyt Chem, Giessen, Germany
来源：
NATURE METHODS | 2017年 / 14卷 / 12期
关键词：
DESORPTION ELECTROSPRAY-IONIZATION; MS;
D O I：
10.1038/nmeth.4433
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe an atmospheric pressure matrix-assisted laser desorption-ionization mass spectrometry imaging system that uses long-distance laser triangulation on a micrometer scale to simultaneously obtain topographic and molecular information from 3D surfaces. We studied the topographic distribution of compounds on irregular 3D surfaces of plants and parasites, and we imaged nonplanar tissue sections with high lateral resolution, thereby eliminating height-related signal artifacts.
引用
收藏
页码：1156 / +
页数：5
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