Iodine-catalyzed C3-formylation of indoles via C-N bond cleavage of tertiary amines under aerobic conditions

被引：19
|
作者：
Lu, Lin [1 ]
Xiong, Qiheng [1 ]
Guo, Shengmei [1 ]
He, Tianqiang [1 ]
Xu, Feng [1 ]
Gong, Jiuhan [1 ]
Zhu, Zheng [1 ]
Cai, Hu [1 ]
机构：
[1] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 22期
基金：
中国国家自然科学基金;
关键词：
Iodine-catalyzed; Formylation; Tertiary amine; Aerobic; ANNULATED GAMMA-CARBOLINES; GREEN CHEMISTRY; ISOEUDISTOMIN U; EUDISTOMIN-U; FORMYLATION; ALKALOIDS; CYANATION; ACYLATION; CHLORIDE; DMSO;
D O I：
10.1016/j.tet.2014.11.069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel route was developed for the C3-formation of indoles using iodine as the catalyst. This transformation involves the cleavage of the C-N bond of tertiary amines by the Cross-Dehydrogenative Coupling reaction (CDC), and is well tolerated by a range of 1H-indoles under aerobic conditions. Moreover, this method can be applied to gram-scale synthesis. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3637 / 3641
页数：5
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