Effect of surgical intervention on circulating tumor cells in patients with squamous cell carcinoma of the head and neck using a negative enrichment technology

被引：20
|
作者：
Jatana, Kris R. [1 ,2 ]
Balasubramanian, Priya [3 ]
McMullen, Kyle P. [2 ]
Lang, Jas C. [2 ]
Teknos, Theodoros N. [2 ]
Chalmers, Jeffrey J. [3 ]
机构：
[1] Nationwide Childrens Hosp, Dept Pediat Otolaryngol Head & Neck Surg, Columbus, OH USA
[2] Ohio State Univ, Dept Otolaryngol Head & Neck Surg, Wexner Med Ctr, Columbus, OH 43210 USA
[3] Ohio State Univ, William G Lowrie Dept Chem & Biomol Engn, Columbus, OH 43210 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷 / 12期
基金：
美国国家科学基金会;
关键词：
circulating tumor cell; squamous cell carcinoma; surgery; immunomagnetic separation; EPITHELIAL-MESENCHYMAL TRANSITION; LYMPH-NODE METASTASIS; BONE-MARROW; CANCER PATIENTS; LUNG-CANCER; PROGNOSTIC-SIGNIFICANCE; PERIPHERAL-BLOOD; BREAST-CANCER; DISSEMINATION; RISK;
D O I：
10.1002/hed.24519
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. The purpose of this study was to investigate the impact of surgical intervention on detection of circulating tumor cells (CTCs) in patients with squamous cell carcinoma of the head and neck (SCCHN.) Methods. We utilized a negative depletion technique to identify cytokeratin (CK)-positive CTCs. The numbers of CTCs immediately before and after surgical resection were compared. Results. Seventy-six blood samples from 38 patients with SCCHN were examined. Seventy-nine percent of the patients had CTCs detected before and after surgery. A total of 7.89% had no CTCs before surgery, yet had CTCs identified after surgery. Overall, 60.5% of patients had an increased number of CTCs/mL after surgery with a mean increase of 6.63-fold. A statistically significant increase in CTCs was seen after surgery (p = .02). Conclusion. The timing of sample collection in patients with SCCHN who have surgical intervention can potentially impact the number of CTCs identified. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码：1799 / 1803
页数：5
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