Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases

被引：79
|
作者：
Fox, AJ
Patel, HJ
Barnes, PJ
Belvisi, MG
机构：
[1] Natl Heart & Lung Inst, Imperial Coll Sch Med, Dept Cardiothorac Surg, Resp Pharmacol Grp, London SW3 6LY, England
[2] Novartis Inst Med Sci, London WC1E 6BN, England
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 424卷 / 02期
关键词：
airway epithelium; neurotrophin; asthma;
D O I：
10.1016/S0014-2999(01)01138-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elevated levels of nerve growth factor (NGF) have been detected in the bronchoalveolar lavage fluid of patients with asthma. However, the source of this enhanced mediator production is not known. Here, we investigate the production of NGF from a human airway epithelial cell line (A549). Under basal conditions, A549 cells generated NGF in a time-dependent fashion. However, basal release was significantly augmented in a concentration-dependent manner in cells treated with interleukin-1 beta (IL-1 beta) or tumour necrosis factor-alpha (TNF-alpha) and inhibited by dexamethasone. These data suggest that NGF released from structural cells may be an important target for the anti-inflammatory effects of steroids in asthma therapy. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：159 / 162
页数：4
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