The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains

被引：4

作者：

de Mooij-van Malsen, Annetrude ^{[1
,2
]}

Pjetri, Eneda ^{[1
,3
]}

Kas, Martien J. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands

[2] CAU Kiel, Inst Physiol, Kiel, Germany

[3] UNC Chapel Hill Nutr Res Inst, Kannapolis, NC 28081 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2015年 / 753卷

关键词：

Behavior; Psychiatry; Drug targets; Endophenotypes; Mouse; Human; MOUSE AVOIDANCE-BEHAVIOR; GENOME-WIDE ASSOCIATION; BIPOLAR DISORDER; EATING-DISORDERS; MOOD DISORDER; SCHIZOPHRENIA; MICE; SUSCEPTIBILITY; CONSORTIUM; SEQUENCE;

D O I：

10.1016/j.ejphar.2014.07.043

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Animal studies play a central role in the identification and testing of novel drugs for CNS disorders. In his longstanding career, Berend Olivier has significantly contributed to CNS drug discovery by applying and supporting novel views and methodologies in the fields of behavioral neuroscience, pharmacology, and (epi-) genetics. Here we review and put forward some of these integrated approaches that have led to a productive collaboration and new insights into the genetic and epigenetic regulation of neurobehavioural traits related to psychiatric disorders. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：135 / 139

页数：5

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