Expression of transcription factor genes in cell lines corresponding to different stages of pancreatic cancer progression

被引：6
|
作者：
Abjalimov, I. R. [1 ]
Zinovyeva, M. V. [1 ]
Nikolaev, L. G. [1 ]
Kopantzeva, M. R. [1 ]
Kopantzev, E. P. [1 ]
Sverdlov, E. D. [1 ]
机构：
[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 475卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
MESENCHYMAL TRANSITION; STROMAL CELLS; TUMOR;
D O I：
10.1134/S160767291704007X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The expression level of six transcription factor genes and the content of their protein products in five pancreatic cancer cell lines with parallel control of expression of three marker genes reflecting epithelial or mesenchymal state of cells was investigated. Cell lines MIA PaCa-2 and Capan-2 represented the best models of quasi-mesenchymal and epithelial, respectively, types of progression of the pancreatic ductal adenocarcinoma, according to the content of E-cadherin and vimentin and the expression of KLF5 and ZEB1 transcription factors.
引用
收藏
页码：267 / 270
页数：4
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