Ovarian Cancer Prevention in High-risk Women

被引：25

作者：

Temkin, Sarah M. ^{[1
]}

Bergstrom, Jennifer ^{[2
]}

Samimi, Goli ^{[3
]}

Minasian, Lori ^{[3
]}

机构：

[1] Virginia Commonwealth Univ, Dept Obstet & Gynecol, Richmond, VA USA

[2] Johns Hopkins Sch Med, Kelly Gynecol Oncol Serv, Baltimore, MD USA

[3] NCI, Div Canc Prevent, Bethesda, MD 20892 USA

来源：

CLINICAL OBSTETRICS AND GYNECOLOGY | 2017年 / 60卷 / 04期

关键词：

ovarian cancer prevention; BRCA; risk-reducing surgery; REDUCING SALPINGO-OOPHORECTOMY; BRCA2 MUTATION CARRIERS; QUALITY-OF-LIFE; TUBAL INTRAEPITHELIAL CARCINOMA; HEREDITARY BREAST; FALLOPIAN-TUBE; GYNECOLOGIC CANCERS; GERMLINE MUTATIONS; SEROUS CARCINOMA; BILATERAL OOPHORECTOMY;

D O I：

10.1097/GRF.0000000000000318

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Ovarian carcinoma is the most lethal malignancy of the female genital tract. Population-based trials in the general population have not demonstrated that screening improves early detection or survival. Therefore, application of prevention strategies is vital to improving outcomes from this disease. Surgical prevention reduces risk and prophylactic risk-reducing salpingo-oophorectomy is the most effective means to prevent ovarian carcinoma in the high-risk patient although the risks do not outweigh the benefits in average risk patients. Other surgical and medical options have unknown or limited efficacy in the high-risk patient. In this review, we define the patient at high risk for ovarian cancer, discuss how to identify these women and weigh their available ovarian cancer prevention strategies.

引用

页码：738 / 757

页数：20

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