L-Proline catalyzed domino Michael addition of N-substituted anilines

被引：16

作者：

Deb, Mohit L. ^{[1
]}

Deka, Bhaskar ^{[1
]}

Rahman, Iftakur ^{[1
]}

Baruah, Pranjal K. ^{[1
]}

机构：

[1] Gauhati Univ, GUIST, Dept Appl Sci, Gauhati 781014, Assam, India

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 50期

关键词：

N-substituted aniline; L-Proline; Michael addition; Domino reaction; Room temperature; MULTICOMPONENT SYNTHESIS; DRUG DISCOVERY; INDOLES; DERIVATIVES; CHEMISTRY; EFFICIENT; KETONES; KINASE;

D O I：

10.1016/j.tetlet.2018.11.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we report L-proline catalyzed 3-component reaction of indoles, aldehydes and N-substituted anilines in water as solvent at room temperature for the synthesis of 3-(alpha,alpha-diarylmethyl)indoles. The reaction is in fact a Michael addition of N-substituted anilines to alkylideneindolenines. The reaction is very clean, high yielding and having broad substrate scope. A tentative mechanism is proposed. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：4430 / 4433

页数：4

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