A Central Move for CB2 Receptors

被引：11
|
作者：
Quraishi, Salma A. [1 ]
Paladini, Carlos A. [1 ]
机构：
[1] Univ Texas San Antonio, UTSA Neurosci Inst, Dept Biol, San Antonio, TX 78249 USA
来源：
NEURON | 2016年 / 90卷 / 04期
关键词：
CANNABINOID RECEPTORS; SYNAPTIC-TRANSMISSION; BRAIN; HIPPOCAMPUS; ACTIVATION;
D O I：
10.1016/j.neuron.2016.05.012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity.
引用
收藏
页码：670 / 671
页数：2
相关论文
共 50 条
  • [31] Binding thermodynamics at the human cannabinoid CB1 and CB2 receptors
    Merighi, Stefania
    Simioni, Carolina
    Gessi, Stefania
    Varani, Katia
    Borea, Pier Andrea
    BIOCHEMICAL PHARMACOLOGY, 2010, 79 (03) : 471 - 477
  • [32] The difference between the CB1 and CB2 cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB2
    Song, ZH
    Slowey, CA
    Hurst, DP
    Reggio, PH
    MOLECULAR PHARMACOLOGY, 1999, 56 (04) : 834 - 840
  • [33] Functional CB2 type cannabinoid receptors at CNS synapses
    Morgan, Nicola H.
    Stanford, Ian M.
    Woodhall, Gavin L.
    NEUROPHARMACOLOGY, 2009, 57 (04) : 356 - 368
  • [34] Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain
    Gong, JP
    Onaivi, ES
    Ishiguro, H
    Liu, QR
    Tagliaferro, PA
    Brusco, A
    Uhl, GR
    BRAIN RESEARCH, 2006, 1071 (01) : 10 - 23
  • [35] Role of cannabinoid CB2 receptors in glucose homeostasis in rats
    Bermudez-Silva, Francisco Javier
    Sanchez-Vera, Irene
    Suarez, Juan
    Serrano, Antonia
    Fuentes, Esther
    Juan-Pico, Pablo
    Nadal, Angel
    Rodriguez de Fonseca, Fernando
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 565 (1-3) : 207 - 211
  • [36] The role of spinal CB2 receptors in the treatment of neuropathic pain
    Shimoyama, Hiroshi
    Masuda, Takahiro
    Yoshinaga, Ryohei
    Nishimoto, Nao
    Tozaki-Saitoh, Hidetoshi
    Tsuda, Makoto
    Inoue, Kazuhide
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118 : 97P - 97P
  • [37] Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders
    Morcuende, Alvaro
    Salud Garcia-Gutierrez, Maria
    Tambaro, Simone
    Nieto, Elena
    Manzanares, Jorge
    Femenia, Teresa
    FRONTIERS IN PSYCHIATRY, 2022, 13
  • [38] Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors
    Govaerts, SJ
    Muccioli, GG
    Hermans, E
    Lambert, DM
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 495 (01) : 43 - 53
  • [39] Cannabinoid CB2 receptors and hypersensitivity to methamphetamine: Vulnerability to schizophrenia
    Canseco-Alba, Ana
    Tabata, Koichi
    Momoki, Yukihiko
    Tabassum, Taharima
    Horiuchi, Yasue
    Arinami, Tadao
    Onaivi, Emmanuel S.
    Ishiguro, Hiroki
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2024, 130
  • [40] Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
    Burston, James J.
    Sagar, Devi Rani
    Shao, Pin
    Bai, Mingfeng
    King, Emma
    Brailsford, Louis
    Turner, Jenna M.
    Hathway, Gareth J.
    Bennett, Andrew J.
    Walsh, David A.
    Kendall, David A.
    Lichtman, Aron
    Chapman, Victoria
    PLOS ONE, 2013, 8 (11):
12345