Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury

被引：47
|
作者：
Zhang, Weilin [1 ]
Chen, Chuyan [2 ,3 ]
Wang, Jun [1 ]
Liu, Lei [1 ]
He, Yubin [4 ]
Chen, Quan [1 ]
机构：
[1] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China
[2] Chinese Acad Med Sci, Beijing, Peoples R China
[3] Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China
[4] Chinese Army Gen Hosp, Heart Ctr, Dept Cardiol, Beijing, Peoples R China
来源：
PHYSIOLOGY | 2018年 / 33卷 / 02期
基金：
北京市自然科学基金;
关键词：
ISCHEMIA-REPERFUSION INJURY; PERMEABILITY TRANSITION PORE; CYTOCHROME-C-OXIDASE; P2Y(12) RECEPTOR ANTAGONIST; REACTIVE OXYGEN; MYOCARDIAL REPERFUSION; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; NLRP3; INFLAMMASOME; RESPIRATORY SUPERCOMPLEX;
D O I：
10.1152/physiol.00030.2017
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Mitophagy, a process that selectively removes damaged organelles by autolysosomal degradation, is an early cellular response to ischemia. Mitophagy is activated in both cardiomyocytes and platelets during ischemia/reperfusion (I/R) and heart disease conditions. We focus on the molecular regulation of mitophagy and highlight the role of mitophagy in cardioprotection.
引用
收藏
页码：86 / 98
页数：13
相关论文
共 50 条
  • [21] Study on cardioprotection of ramipril against ischemia-reperfusion injury in diabetic rats
    Wu Yan-Na
    Zhang Zhe
    Chen Yan
    Jiao Jian-Jie
    Kang Yi
    Gao Wei-Zhen
    Lou Jian-Shi
    Liu Yan-Xia
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 261P - 261P
  • [22] Mitochondrial Permeability Transition Pore and Cardioprotection Against Ischemia-reperfusion Injury
    Lee, Jong Wha
    Shim, Yon Hee
    JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, 2009, 52 (10): : 1007 - 1019
  • [23] Survivin: A novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury
    Si, Rui
    Tao, Ling
    Zhang, Hai F.
    Yu, Qiu J.
    Zhang, Rui
    Lv, An L.
    Zhou, Ning
    Cao, Feng
    Guo, Wen Y.
    Ren, Jun
    Wang, Hai C.
    Gao, Feng
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 50 (01) : 16 - 24
  • [24] Mitochondrial events responsible for morphine's cardioprotection against ischemia/reperfusion injury
    He, Haiyan
    Huh, Jin
    Wang, Huihua
    Kang, Yi
    Lou, Jianshi
    Xu, Zhelong
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2016, 290 : 66 - 73
  • [25] CARDIOPROTECTION OF ISCHEMIC POSTCONDITIONING IN SENESCENT RAT HEARTS AGAINST ISCHEMIA/REPERFUSION INJURY
    Zhang, Cun-Tai
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (13) : E447 - E447
  • [26] Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
    Suzuki, M
    Sasaki, N
    Miki, T
    Sakamoto, N
    Ohmoto-Sekine, Y
    Tamagawa, M
    Seino, S
    Marbán, E
    Nakaya, H
    JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (04): : 509 - 516
  • [27] Secoisolariciresinol diglucoside: Relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury
    Penumathsa, Suresh Varma
    Koneru, Srikanth
    Thirunavukkarasu, Mahesh
    Zhan, Lijun
    Prasad, Kailash
    Maulik, Nilanjana
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 320 (02): : 951 - 959
  • [28] The effect of sevoflurane postconditioning on cardioprotection against ischemia-reperfusion injury in rabbits
    Dong Chen
    Bo Cheng
    Hai-Yan Zhou
    Li-Huan Li
    Molecular Biology Reports, 2012, 39 : 6049 - 6057
  • [29] The effect of sevoflurane postconditioning on cardioprotection against ischemia-reperfusion injury in rabbits
    Chen, Dong
    Cheng, Bo
    Zhou, Hai-Yan
    Li, Li-Huan
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (05) : 6049 - 6057
  • [30] A possible mechanism underlying cardioprotection of nicorandil against ischemic/reperfusion injury
    Iwai, T
    Tanonaka, K
    Motegi, K
    Inoue, R
    Kasahara, S
    Takeo, S
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (06) : A170 - A170
12345