[1] Fernando Pessoa Univ, Fac Hlth Sci, P-4200150 Oporto, Portugal
[2] Univ Porto, Lab Pharmaceut Technol, Ctr Res Pharmaceut Sci, Fac Pharm, P-4100 Oporto, Portugal
[3] Fernando Pessoa Univ, FP ENAS, UFP Energy Environ & Hlth Res Unit, CEBIMED,Biomed Res Ctr,Fac Hlth Sci, P-4200150 Oporto, Portugal