Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma: A case report with a review of the Literature

被引：8

作者：

Goto, Naoe ^{[1
,2
]}

Tsurumi, Hisashi ^{[1
]}

Sawada, Michio ^{[3
]}

Kanemura, Nobuhiro ^{[1
]}

Hara, Takeshi ^{[1
]}

Kasahara, Senji ^{[1
]}

Kito, Yusuke ^{[2
]}

Takada, Katsuyoshi ^{[4
]}

Sato, Yasuharu ^{[4
]}

Yoshino, Tadashi ^{[4
]}

Moriwaki, Hisataka ^{[1
]}

Takami, Tsuyoshi ^{[2
]}

机构：

[1] Gifu Univ, Dept Internal Med 1, Grad Sch Med, Gifu 5011194, Japan

[2] Gifu Univ, Dept Immunopathol, Grad Sch Med, Gifu 5011194, Japan

[3] Gifu Red Cross Hosp, Dept Hematol, Gifu, Japan

[4] Okayama Univ, Dept Pathol, Grad Sch Med Dent & Phamaceut Sci, Okayama 7008530, Japan

来源：

PATHOLOGY INTERNATIONAL | 2011年 / 61卷 / 05期

关键词：

follicular variant PTCL; follicular T-helper cells; phenotype; GROWTH-PATTERN; HELPER-CELLS; IDENTIFICATION; INVOLVEMENT;

D O I：

10.1111/j.1440-1827.2011.02656.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Peripheral T-cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50-year-old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3+ CD4+ CD5+ CD8- CD10+ CD56- CD57- BCL6+ PD-1+ CXCL13+ and were associated with a meshwork of CD21+ follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T-cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T-helper cells.

引用

页码：326 / 330

页数：5

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