On the complexity of fundamental computational problems in pedigree analysis

被引：21

作者：

Piccolboni, A ^{[1
]}

Gusfield, D ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Comp Sci, Davis, CA 95616 USA

来源：

JOURNAL OF COMPUTATIONAL BIOLOGY | 2003年 / 10卷 / 05期

关键词：

linkage analysis; computational complexity; pedigree;

D O I：

10.1089/106652703322539088

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Pedigree analysis is a central component of many current efforts to locate genes that contribute to diseases or to valuable traits. The analysis usually involves solving one of two very computation-intense problems. We analyze the complexity of these two problems. Surprisingly, we show that both problems are NP-hard even for pedigrees that contain no inbreeding loops.

引用

页码：763 / 773

页数：11

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