Chiral Bronsted acid catalyzed intermolecular Friedel-Crafts alkylation of styrenes with indoles: construction of all-carbon quaternary stereocenters

被引：33
|
作者：
Li, Ming-Li
Chen, Dian-Feng
Luo, Shi-Wei
Wu, Xiang [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 2015年 / 26卷 / 04期
基金：
中国国家自然科学基金;
关键词：
ORTHO-QUINONE METHIDES; ENANTIOSELECTIVE CONSTRUCTION; ORGANOCATALYTIC CHEMO; ASYMMETRIC-SYNTHESIS; FUNCTIONALIZATION; ACTIVATION; CENTERS;
D O I：
10.1016/j.tetasy.2015.01.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A chiral Bronsted acid catalyzed Friedel-Crafts reaction of terminal 1,1-diaryalkenes with indoles is described. This reaction provides indole derivatives with acyclic all-carbon quaternary stereocenters in excellent yields and with excellent enantioselectivities, and features high atom efficiency without the generation of side products. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：219 / 224
页数：6
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