Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research

被引：37

作者：

Morselli, Eugenia ^{[1
]}

Frank, Aaron P. ^{[2
]}

Santos, Roberta S. ^{[3
,4
]}

Fatima, Luciana A. ^{[5
]}

Palmer, Biff F. ^{[6
]}

Clegg, Deborah J. ^{[2
]}

机构：

[1] Pontificia Univ Catolica Chile, Dept Physiol, Fac Biol Sci, Santiago 8331150, Chile

[2] Cedars Sinai Diabet & Obes Res Inst, Dept Biomed Res, Los Angeles, CA 90048 USA

[3] Univ Estadual Campinas UNICAMP, Inst Biol, Dept Biol Estrutural & Func, BR-13083970 Campinas, SP, Brazil

[4] Univ Estadual Campinas UNICAMP, Ctr Pesquisa Obesidade & Comorbidades, BR-13083970 Campinas, SP, Brazil

[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508000 Sao Paulo, SP, Brazil

[6] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

来源：

CELL METABOLISM | 2016年 / 24卷 / 02期

关键词：

CARDIOVASCULAR-DISEASE; X-CHROMOSOME; RISK-FACTORS; MYOCARDIAL-INFARCTION; NATURAL MENOPAUSE; MORTALITY; TESTOSTERONE; MEN; ESTRADIOL; WOMEN;

D O I：

10.1016/j.cmet.2016.07.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this Essay, we discuss the critical need to incorporate sex and gender in pre-clinical and clinical research to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender. This knowledge will allow for development of personalized medicine which will optimize therapies specific for individuals.

引用

页码：203 / 209

页数：7

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