Peptide-based cancer vaccines

被引：68
|
作者：
Melief, CJM [1 ]
Offringa, R [1 ]
Toes, REM [1 ]
Kast, WM [1 ]
机构：
[1] LOYOLA UNIV, CARDINAL BERNADIN CANC CTR, CANC IMMUNOL PROGRAM, MAYWOOD, IL 60153 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0952-7915(96)80081-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The application of molecularly defined vaccines composed of a limited number of tumor-specific T cell epitopes has resulted in protective antitumor T cell immunity in several mouse tumor models. The first encouraging results with such vaccines have been obtained in human beings. The development of the next generation of rationally designed vaccines that are both effective and safe for application in a clinical setting requires comparison of different modes of delivery of tumor-associated T cell epitopes in multiple epitope constructs.
引用
收藏
页码：651 / 657
页数：7
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