Solid-phase synthesis of peptide-derived enantiospecific nucleic acid analogs

The first solid-phase synthesis of novel peptide-derived enantiospecific nucleic acid analogs (PDNAs), employing all three stereoisomers of 4-(N-9-adeninyl)-2-amino(t-boc)-butyric acid as ADNA (amino acid-derived nucleoside analogs) monomers has been described. The preliminary melting temperature (T-m) data obtained by hybridization experiments demonstrated that these PDNAs can anneal to their complementary nucleic acid strand dT(10). (C) 1996 Academic Press, Inc.