HLA-E polymorphisms in hematopoietic stem cell transplantation

被引：22
|
作者：
Fuerst, D. [1 ,2 ]
Bindja, J. [1 ,2 ]
Arnold, R. [3 ]
Herr, W. [4 ]
Schwerdtfeger, R. [5 ]
Mueller, C. H. [6 ,7 ]
Recker, K. [1 ,2 ]
Schrezenmeier, H. [1 ,2 ]
Mytilineos, J. [1 ,2 ,7 ]
机构：
[1] Baden Wuerttemberg Hessia, German Red Cross Blood Transfus Serv, Inst Clin Transfus Med & Immunogenet Ulm, Dept Transplantat Immunol, Ulm, Germany
[2] Univ Clin Ulm, Inst Transfus Med, Transplantat Immunol Lab, Ulm, Germany
[3] Charite Campus Virchow, Dept Hematol Oncol, Berlin, Germany
[4] Univ Clin Mainz, Dept Hematol Oncol, Mainz, Germany
[5] DKD Wiesbaden, Ctr Blood & Bone Marrow Transplantat, Wiesbaden, Germany
[6] ZKRD German Natl Bone Marrow Donor Registry, Ulm, Germany
[7] DRST German Registry Stem Cell Transplantat, Ulm, Germany
来源：
TISSUE ANTIGENS | 2012年 / 79卷 / 04期
关键词：
CD94; hematopoietic stem cell transplantation; HLA-E; HSCT; natural killer cell; NKG2A; PROPORTIONAL HAZARDS MODEL; BONE-MARROW; E BINDS; SUBDISTRIBUTION; ASSOCIATION; EXPRESSION; MORTALITY;
D O I：
10.1111/j.1399-0039.2011.01832.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Human leukocyte antigen (HLA)-E is an inhibitory ligand of natural killer cells and ?/d T-cells. Differential expression of HLA-E alleles on the cell surface has been reported to influence outcome of hematopoietic stem cell transplantation (HSCT). We performed HLA-E genotyping in 116 HSCT patients and their HLA-matched unrelated donors. The impact of HLA-E genotypes on patient's overall survival (OS), disease free survival (DFS), cumulative incidences for relapse, transplant-related mortality (TRM) and acute graft vs host disease (aGvHD) was assessed. Neither univariate nor multivariate analysis showed any influence of HLA-E polymorphisms on the investigated endpoints of HSCT in our cohort. We could not confirm any of the previous observations in our cohort and consider it unlikely that HLA-E polymorphisms affect outcome of HSCT.
引用
收藏
页码：287 / 290
页数：4
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