Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan

被引：15

作者：

Cui, Zi-Ning ^{[1
]}

Shi, Yan-Xia ^{[2
]}

Cui, Jing-Rong ^{[3
]}

Ling, Yun ^{[1
]}

Li, Bao-Ju ^{[2
]}

Yang, Xin-Ling ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Coll Sci, Key Lab Pesticide Chem & Applicat,Minist Agr, Beijing 100193, Peoples R China

[2] Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China

[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2012年 / 79卷 / 01期

基金：

中国国家自然科学基金;

关键词：

5-phenyl-2-furan; antifungal activity; antitumor activity; pyrazole and triazole derivatives; synthesis; N; N'-DIACYLHYDRAZINE DERIVATIVES; INSECTICIDAL ACTIVITY; DIACYLHYDRAZINE; FURAN;

D O I：

10.1111/j.1747-0285.2011.01266.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized. Their toxicities were predicted using in silico assays and proven to be less toxic. The antitumor results showed that the activity of compounds containing 1,3,4-triazole (series II) was higher than that of pyrazole-attached derivatives (series I). Among them, IIa and IIg showed much higher activity against Bel-7402 than doxorubicin. The fungicidal tests showed that most title compounds II exhibited great selectivity against Phytophthora capsici in vivo.

引用

页码：121 / 127

页数：7

共 50 条

[31] Synthesis and Bioactivities of Novel N-1,2,4-Triazole Moieties Imines Containing Fluorocinnamylidene
Li, Qianzhu
Song, Baoan
Cai, Xuejian
Zheng, Yuguo
Guo, Qingqing
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2010, 30 (04) : 569 - 575
[32] Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents
Chu, Ming-Jie
Wang, Wei
Ren, Zi-Li
Liu, Hao
Cheng, Xiang
Mo, Kai
Wang, Li
Tang, Feng
Lv, Xian-Hai
MOLECULES, 2019, 24 (07)
[33] Synthesis and characterization of novel polyampholyte and polyelectrolyte polymers containing imidazole, triazole or pyrazole
Lazaro Martinez, Juan M.
Chattah, Ana K.
Torres Sanchez, Rosa M.
Buldain, Graciela Y.
Campo Dall'Orto, Viviana
POLYMER, 2012, 53 (06) : 1288 - 1297
[34] Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing a 2-Chloro-5-thiazolyl Moiety
Dai, Hong
Li, Yong-Qiang
Du, Ding
Qin, Xue
Zhang, Xin
Yu, Hai-Bo
Fang, Jian-Xin
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (22) : 10805 - 10810
[35] Synthesis and Properties of Furan Derivatives. 5. Synthesis of 2-Substituted Benzoxazoles Containing Furan Fragments
Kelarev, V. I.
Koshelev, V. N.
1996, (32)
[36] Synthesis and herbicidal activity of novel 1,2,4-triazole derivatives containing fluorine, phenyl sulfonyl and pyrimidine moieties
Yang, Lingyun
Sun, Yi
He, Linghui
Fan, Yujia
Wang, Tao
Luo, Jin
JOURNAL OF MOLECULAR STRUCTURE, 2022, 1259
[37] Synthesis and herbicidal activity of novel 1,2,4-triazole derivatives containing fluorine, phenyl sulfonyl and pyrimidine moieties
Yang, Lingyun
Sun, Yi
He, Linghui
Fan, Yujia
Wang, Tao
Luo, Jin
Journal of Molecular Structure, 2022, 1259
[38] Synthesis and Configuration of Novel Isoxazole Derivatives Containing Pyrazole Moiety
Zhou, Yinglei
Shen, Songwei
Liu, Fangming
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2010, 30 (09) : 1342 - 1346
[39] Synthesis and antifungal activity of the novel triazole derivatives containing 1,2,3-triazole fragment
Yu, Shichong
Wang, Nan
Chai, Xiaoyun
Wang, Baogang
Cui, Hong
Zhao, Qingjie
Zou, Yan
Sun, Qingyan
Meng, Qingguo
Wu, Qiuye
ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (10) : 1215 - 1222
[40] Synthesis and antifungal activity of the novel triazole derivatives containing 1,2,3-triazole fragment
Shichong Yu
Nan Wang
Xiaoyun Chai
Baogang Wang
Hong Cui
Qingjie Zhao
Yan Zou
Qingyan Sun
Qingguo Meng
Qiuye Wu
Archives of Pharmacal Research, 2013, 36 : 1215 - 1222

← 1 2 3 4 5 →