A novel and facile synthesis of 3-(2-benzofuroyl)- and 3,6-bis(2-benzofuroyl)carbazole derivatives

被引：12
|
作者：
Gao, Wentao [1 ]
Zheng, Meiru [1 ]
Li, Yang [1 ]
机构：
[1] Bohai Univ, Inst Superfine Chem, Jinzhou 121000, Peoples R China
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 7卷
关键词：
2-benzofuroyl; carbazole; PEG-400; Rap-Stoermer reaction; salicylaldehydes; ultrasound-assisted; ONE-POT SYNTHESIS; BENZOFURAN DERIVATIVES; CARBAZOLE; EFFICIENT; AGENTS; ELLIPTICINE; DESIGN; 1ST;
D O I：
10.3762/bjoc.7.180
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile synthesis of hitherto unreported 3-(2-benzofuroyl)carbazoles 3a-k, 3,6-bis(2-benzofuroyl)carbazoles 5a-k, and naphtho[2,1-b]furoylcarbazoles 3l and 5l is described. The synthesis mainly relies on the ultrasound-assisted Rap-Stoermer reaction of 3-chloroacetyl- (1) or 3,6-dichloroacetyl-9-ethyl-9H-carbazole (4) with various salicylaldehydes 2a-k as well as 2-hydroxy-1-naphthaldehyde (2l) in CH3CN with the presence of PEG-400 as catalyst. The procedure offers easy access to benzofuroylcarbazoles in short reaction times and the products are obtained in moderate to good yields.
引用
收藏
页码：1533 / 1540
页数：8
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